In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A University of California, Riverside team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development. The team reports in the Proceedings of the National Academy of Sciences that it...

A UC Riverside-led study focusing on an oncoprotein called MYC has discovered a new MYC signaling mechanism that is deregulated in cancer cells. This mechanism, called MYC lysine-acetylation, activates specific genes that make mammary cells malignant and drives the tumor-promoting functions of MYC, including the ability of cancer cells to survive and proliferate even without...

A multiyear cancer-research project, stemming from a newly established partnership between the University of California, Riverside, and the City of Hope – Comprehensive Cancer Center (CoH-CCC), has received funding from the National Cancer Institute (NCI) of the National Institutes of Health to develop collaborations, resources, and training programs aimed at reducing disparities in cancer research...